The problem with Bootstrap is that it depends on jQuery and Popper, and its CSS has global classes. It’s perfectly fine if BS is the only UI framework, but if you need to bring to bring in other frameworks or libraries (by choice or by force), then there’s a chance you’ll run into conflicts.
Unless you’re stuck on an older version. Also there is a jQuery resolver still embedded even in the latest version that looks for jQuery and tries to use it if it’s globally defined. Caused some nasty bugs in certain Enterprise applications and I have had to manually gut this from the official release.
