The research and science being done is measuring levels of stress relative to shapes and designs of buildings through eye-tracking software. So to really over-simplify, buildings that are asymmetrical or perhaps where the door is hard to find, or in some urban environments there specific features that cause stress and it is measurable.
> The environment humans evolved in (the natural world) doesn't have much of anything symmetrical, unless it was built by humans.
https://www.sciencekids.co.nz/images/pictures/plants/flower....