A single threaded Zen2 program could very well take 1 second to scan through your RAM, during which it's entirely trivial to read stuff from disk, so the modern practice of keeping a ton of stuff in RAM might be actually hurting performance.

Algorithms, such as garbage collection, which scan the entire heap, where the single-threaded version is probably slower than the naive zen 2 memcpy might run for more than a second even on a comparatively modest 16GB heap, which might not be even acceptable.