Yes, Perforce handles large files, and large folders of files, very well. It's quite efficient with deltas in binary files. It's also very useful that Perforce expects clients to check out only a part of the depot. There are folders with raw assets like uncompressed sound, layered graphics and all that, I don't check out any of that, I only check out the necessary in-engine assets.
For code, I prefer git as I said, but in a game's depot most files are not code, and Perforce is built around handling those other assets well.
