It is tricky of course, but that is the state of play. I wish it wasn't that way.
As someone that used to travel weekly, I used to go with Thinkpads or a Zenbook as both I was able to fix whilst away (the former had a keyboard issue, and the latter a HDD issue). I am yet convinced on the long term durability of the Framework but I have had it a year and it is pretty good still. No different in issues than any other laptop I have used in recent times. Overall for the quality I am pretty happy as I have used a lower cost laptop for various reasons and found I was always anxious of breaking it.
The big thing I do feel I am missing when doing 3D work is a dedicated GPU for simulations but then that would reduce the battery life too much day to day.