Biology was forced to deal with the insanity of biochemistry because that’s what is actually happening. Economics can’t get away from the innate complexity of actual humans if it wants to be actually useful for more than just propaganda.
Economics chooses to impose assumptions that peoples observed choices are a better way to study their behavior than what they say, and so we look at the observable state of the world for an individual economic agent. You can do analysis of people whose preferences are not rational (in the strict mathematical sense that I described above) but you must choose what kind of irrationality they have. And that gives you the ability to assume any results. That isn't any way to do science. Rationality is the worst option except for all the rest as they say.
You don’t need to read people’s minds to predict their behavior at sufficient granularity to be useful. Economics is blessed with plenty of opportunities to collect high quality real world data without needing to conduct arbitrary experiments.
How much gas will this specific gas station sell on date X. Build whatever models you want at whatever scale is relevant and they face the brutal truth of a knowable answer to judge them. That’s how science progresses not arbitrary assumptions to make modeling easier.
Do you see the issue here when I frame it this way? The core microeconomic assumption of people having preferences which are complete, reflexive and transitive (these are formal mathematical definitions! They don't require a whole lot to hold!) has been incredibly useful in the 20th and 21st centuries much like understanding Newtonian mechanics was in the 18th and 19th centuries.
Besides this, you are still not engaging with the philosophy of science point that I am making. Because of the fact that humans have this pesky thing called free will, unless we impose some assumptions on their thinking nothing we study about causality in the behavior of humans is falsifiable. Maybe you eat because you feel hungry. Maybe you eat because you worship bread as a god. I fundamentally can't say either way without making assumptions that you likely find unobjectionable.
This is dumb. There are plenty of cases where predicting the rational outcome and measuring an empirical gap from it reveals opportunity.
