For the Varnish TinyKVM vmod they brought up examples of running image transcoding which is definitely something that benefits from per request isolation given the history of exploits for those kinds of C/C++ libraries.
It's worth noting that Cloudflare/AWS Lambda don't have per-request isolation and that's pretty important for server side rendering use cases where code was initially written with client side assumptions.
Not sure this will ever turn into a business for me personally - my motivation is in trying to regain some of the simplicity of the CGI days without giving up the performance gains of modern software stacks. Though it would be helpful to have a production workload to improve at some point.