If request payload exceeds certain size the response latency goes from network RTT to double that, or triple.
Definitely something wrong with either TCP or HTTP/2 windowing as it doesn't send the full request without getting ACK from server first. But none of the gRPC windowing config options nor linux tcp_wmem/rmem settings work. Sending one byte request every few hundred milliseconds fixes it by keeping the gRPC channel / TCP connection active. Nagle / slow start is disabled.
It's head-of-line blocking. When requests are serialized, the queue will grow as long as the time to service a request is longer than the interval between arriving requests. Queue growth is bad if sufficient capacity exists to service requests in parallel.
At least try something else besides gRPC when building systems so you have a baseline performance understanding. gRPC is OFTEN introducing performance breakdowns that goes unnoticed.