I first read this as referring to Trump but I can't quite place the rest of the comment. Do you mean whoever is in charge of Iran or is it a way of saying both/either?
Supreme Leader (officially Supreme Leadership Authority) is the head of state of Iran, combining both political and religious ultimate power, appointed for life.
Iran believes in martyrdom, which absolutely changes the reasoning. They would destroy Israel in a heartbeat even if it meant losing 90% of their population.