Not really. Caffeine tolerance builds over a period of days and dissipates over a similar period, roughly 72 hours. The article actually touches on the effect, and it has to do with a reduction of adenosine receptors in middle-aged participants.
> “Adenosine receptors naturally decrease with age, reducing caffeine’s ability to block them and improve brain complexity, which may partly explain the reduced effect of caffeine observed in middle-aged participants,” Carrier said.
