Absolutely! However, I believe users aren't the issue. Hiring managers, HR, etc. absolutely give a fuck about whether you're using React or plain JS.
I have a friend that is a recruiter for a moderately sized company. She said that when they were looking for a frontend developer, if one's resume listed Angular and not React, then your resume was instantly thrown away. Not even a second of consideration was given.
I am not sure how common that is within the industry as a whole, but it wouldn't surprise me if it's quite common. It's shit like this that makes me absolutely hate our industry. I love programming, but I am really beginning to hate doing it for an occupation.
I come from the old school way too. I still publish applications in 2025 with just plain HTML, CSS, JS, and .Net backend. Nothing fancy. However, I am feeling compelled to learn React (against my will) sheerly for job prospects. My users nor my employer would benefit from React, but I've been considering using it sheerly for 'Resume Drive Development.'