Ideally, BIOS/CSM systems should not care about what type of partition table format a disk uses, and just boot by loading the boot sector (the 1st sector), and passing control to it.

In the real world, some machines will check for whether an MBR exists (by MBR meaning the partition table contained in the first sector, also called "msdos" partition table, naming varies depending on who you ask), some of them will check whether there is any partition set as active in said MBR, some of them will, indeed, check if there is a GPT (past any protective MBR), and ignore such disks - possibly because firmware writers thought that no GPT disk should be bootable on BIOS systems (Windows doesn't support it, so...), to avoid passing control to an empty protective MBR and possibly crash or hang as a result.