I've been doing frontend development for over 10 years, and obviously it's anecdotal but I never heard anyone use the Closure Compiler outside of ClojureScript, and I imagine that in practice most people doing frontend development are using Webpack, Vite, Parcel, etc. The idea of really small bundles sounds nice, but in practice because the advanced optimizations require manual tweaking in many cases to get it to work (externs) it's something few people would want to deal with and the small bundle size improvement isn't worth it compared to the standard tools like UglifyJS/Terser.

There may be other reasons, but I assume the main reason that the Closure Compiler was chosen for ClojureScript was because it's Java based, so it was straightforward to get working. Moving away from it now would be a huge breaking change, so it's unlikely to happen in the official compiler anytime soon or ever. I think the only way it would actually happen is if an alternative like Cherry got enough traction and people moved to using mainly the alternative.