I doubt there is one single grand answer for the Fermi Paradox. Probably it's lots of smaller blockers which all stack up with each other. The chance of life forming, the chance that it becomes multicellular, the chance that it develops complex nervous systems, intelligence, the physiological hardware for tool use and creation, not stagnating or getting wiped out, having the inclination to look out and broadcast their existence, the chance that they survive long enough while doing this to exist at the same time as another civilization of comparable development, etc. It's easy to come up with these and even if they all have modestly small probabilities each, together they stack up to a plausible answer to the so called paradox.