The days of large aircraft are in no way "numbered". In order to have enough range to operate in the Indo-Pacific Theater that requires a lot of fuel, which implies a large aircraft (regardless of whether it's manned or unmanned). And while AI might eventually be effective at controlling combat aircraft, as of today that remains science fiction. So that means you need a person either directly in the combat aircraft, or actively controlling a large "loyal wingman" type drone from within line of sight (to ensure reliable communications in a hostile EW environment).