The ergonomics of compiling your code for every combination of architecture and platform you plan to deploy to? It's not fun. I promise.
> my default assumption to use JS runtimes on the server
AWS Lambda has a minimum billing interval of 1ms. To do anything interesting you have to call other APIs which usually have a minimum latency of 5 to 30ms. You aren't buying much of anything in any scalable environment.
> there is decreasing utility in familiarity with a language to be productive.
I hope you aren't planning on making money from this code. Either way, have fun debugging that!
> the advantages of scripting languages are being eroded away.
As long as scripting languages have interfaces which let them access C libraries either directly or through compiled modules they will have strong advantages. Just having a CLI where you can test out ideas and check performance is massively powerful and I hate not having it in any compiled project. Go has particularly bad ergonomics here as writing test cases are easy but exploring ideas is not due to it's strictness down to even the code styling level.