I'm currently seeing 12ms latency to my upstream NextDNS server. On my home network I "proxy" it with a forwarding/caching DNS server on my router, so for "the usual suspects", latency is not an issue.
On the go, over 5G, those 12ms won't make much of a difference.
Considering that people deploy PiHole on Raspberry Pi W models, over wifi, you won't lose much running NextDNS, but you gain dns blacklisting on all networks, as opposed to just your home network (or via VPN)