I don't think that the developers of Slay The Spire were taught by complexity loving professors, no. But education does more than influence the people at universities. Education informs norms, traditions, and styles that permeate through industries. An example from outside tech: the music notation app Finale found a strangle hold on the education market, and now it's one of the standards for notation, despite being the worst option (source: have you tried Finale?).

I've never played the game, but my understanding is that Slay the Spire largely impresses on a design and artistic front, not a technical one. Its engine requirements were not based on feature set or code quality, but on what developers knew. So they probably picked Unity because it was ubiquitous. Education starts the problem, and then devs who need something common they care hire for continue the problem. I don't blame devs for this, it's the right choice to make and obviously Slay the Spire is great, but I am saying that this is a force that drives down the quality of game engines.