Yeah, I was doing 5x5 forever. It is a good starter, but you will plateau.
Everyone will have their own methods here, but after years of having marginal growth per year I changed it up.
I now only do 1 set per exercise, 3-4 exercises per day. For arm focused exercises I do 15 reps in 1 set. For everything else, I do 20 reps for a set.
If I succeed, then I up the weight for the next exercise (2.5lbs for arms, 5lbs for everything else).
If I fail, I do a drop set and shave off 20% per set taking just 30 seconds per drop.
I use the drop set as both the thing to help the growth, and the thing to punish me for failing to increase the initial set. If I get my 20 reps, I get to move on, so I push really hard because the drop set totally sucks.
If I fail 3 weeks in a row, I drop the weight.
Been doing this for the last two years and I am 47, and each year I have increased my strength by 20-40% depending on the exercise.
I also keep the number of exercises per day to be minimal. With 5 days in the week, I do just 3-4 exercises per day. M, W, R are 1-2 from the 5x5 program (squats, deadlifts, bench, should-to-overhead, rows) along with some extras that I want to focus on. Tues, Thur are more extras, and ones that I am willing to sacrifice if I have a busy week. This means I can still hit the gym just 3 days a week, and hit the core exercises. Also, the core exercises are rough, so Tue/Thur are almost like easy days.
Here is my schedule:
M:
Bench,
20degree lying dumbell curl,
Squat
Tues:
Lat Raises,
Hip Thrusts,
Neck exercises (put a plate on your head and do lifts from 4 different angles while lying down)
Wed:
Overhead press,
Deadlift,
Cable Row
Thur:
Tricep Rope
Kettlebell swing
Lat Pull down
Fri:
Dumbbell Bench
Dumbbell Shoulder
Barbell Row
Front Squat
You'll notice their are some repeats in there with cables and dumbbells. This is helps hit the muscle groups twice a week, but with some variation and some different stabilization. I chart all this in a google spreadsheet with each column being a week so I can see my progress, and so I can see if I missed anything from the core days in the week, and I happily change up days so I ALWAYS hit the core 3 day exercises.