I think there are actually two questions there:
1. Is it possible for a view of the world in which humans aren’t at the center, but still flourish? I think the answer is…possibly; but I am a little, but not extremely, skeptical. I think human psychology seems to benefit from thinking we’re at the center of things, or at least that we aren’t merely another random creature in space.
2. The more interesting question is whether this is even possible, given the apparent nature of existence. I’m not an expert on quantum physics, but from my layman understanding, the observer necessarily affects the observed. Which would seem to imply that the observer is necessarily at the center of their own vision of the universe, even on a physical level. Again, I’m not sure how that spells out in physics and I could be mistaken in my understanding here, but: it does seem like the vision of the universe as this independent thing which humans move around on is a cultural legacy and not how reality actually is constructed.
On that last note - not sure I necessarily agree there. I think the unstated meta-purpose of natural sciences is to gain more information, with the assumption that more information is necessarily good. Scientists seem more driven by a desire for knowledge than a desire for human flourishing, to me.