The second time around they have a plan, project 2025. It's not trump's plan but they'll do it in his name anyway, if not they can always 25th amendment him and have Vance instead. The authors and their acolytes will all be in his cabinet. They have the presidency, the house, senate, supreme court and already have many federalist society judges in place.
Will they be able to do everything in the plan? Probably not. Is it likely that they'll do great damage to the federal government and hurt many people? Yes, they're set up to do so already. Will states be able to resist? Maybe, the right is all for states rights but they're also hypocrites so I have my doubts.