I'm not a chemist, biologist, or pharmacologist, but wouldn't it be more reasonable to be cautious based on how analogous the method of action is to other drugs, rather than the effect? GLP-1s don't work in the same manner that phen/fen did, for example.
DNP is an extremely effective drug for weight loss, but no one who knows anything about how it works would think that it would be reasonable to compare it to the GLP-1s, and anyone who knows how it works would also plainly see the dangers around its use.
GLP-1 type drugs have been on the market for decades now as well, and while they are not perfectly safe, we've got a good amount of data around the short to medium term side effects.
