IMO Durable Objects map well to use cases where there actually are documents. Think of Figma. There is a ton of data that lives inside the literal Figma document. It would be awful to have a relational table for like "shapes" with one row per rectangle across Figma's entire customer base. That's just not an appropriate use of a relational database.
So let's say I built Figma on MongoDB, where each Figma document is a Mongo document. That corresponds fairly straightforwardly to each Figma document being a Durable Object instance, using either the built-in noSQL storage that Durable Objects already have, or a small Sqlite relational database which does have a "shapes" table, but only containing the shapes in this one document.