If you actually read the effectiveness and safety research with a critical eye, you would realize “rigorous” is often the wrong adjective, whereas “cherry picked” to the point of “fraudulent” is often more in line with reality.
Case in point: 50,000 people died, with about 5 times as many suffering life-changing serious adverse events, from “rigorous research” on the safety of Vioxx. Yes, it has since been pulled from the market, which FDA apologists often construe as “system working as designed”. No, it isn’t, even in the least, when you go into the details.
Also: Purdue and OxyContin.
Regulatory capture of the FDA is decades old at this point. Ignoring that is not a rational or healthy position.