TypedDicts "aren't real" in the sense that they're a compile-time feature, so you're getting typing without any deserialization cost beyond the original JSON. Dataclasses and Pydantic models are slow to construct, so that's not nothing.
This of course means TypeDicts don't give you run-time validation. For that, and for full-blown custom types in general, I tend to favor msgspec Structs: https://jcristharif.com/msgspec/benchmarks.html#json-seriali....