* You can't share your screen in a way optimized for text clarity. In the native app, even without nitro, you, effectively, have the "source resolution, 5 fps" option. With the web app, you are limited to 720p.

* You can't make the full use of your camera. On the web, 640x480 is the only available resolution, while in the native app, 1280x720 is the default.

* Also, on platforms other than Linux, with the native app, you can stream the game audio separately from your microphone. This functionality is not available via the web or on Linux unless you install an unofficial client.