I think the word blockchain confuses people, including you and the previous poster. Maybe you could clarify your “layering” idea and how it would work for further discussion.
Folding at home can track user contributions and issue micro/payments as they see fit. Crucially, this does not need an immutable chain of truth to do.
Instead, if we added a blockchain, then we would require 2 sets of participants - those who run the useful simulations for science, and those who run the useless calculations for the blockchain. A complete waste of resources.