In chemistry only very simple stuff works the first time you try it. Even skilled chemists usually fail to replicate research papers, especially in organic chemistry. It's very frustrating. Lots of work, lots of cleaning up.

Pretty much all the chemistry you see on youtube can be considered simple. Even the cubane synthesis, which Extractions&Fire epically failed at, was undergrad stuff at my university. Chemiolis nailed it, I think.

Other great chemistry channels that come to my mind are Chemical Force (breathtaking slowmo videos), Thy Labs, Thoisoi, Prussian Blue, Chemdelic, not exhaustive.