This is largely the motivation for TAILS:
https://en.wikipedia.org/wiki/Tails_(operating_system)And also Whonix: https://en.wikipedia.org/wiki/Whonix
Using the DVD image in a VM would largely suffice for most users. For even more security, you would use the live image on a throwaway laptop at a coffee shop or something, but that's not exactly practical for everyday use.