The problem time immortal is language complexity vs the ability to hint to your compiler that it can make much stronger assumptions about your code than it has to assume naturally which is where we got __slots__. And there's lots of easy wins you could get in Python that eliminate a significant amount of dynamism-- you could tell your compiler that you'll never shadow names for example, that this list is fixed size, that you don't want number promotion but they all require adding stuff to the language to indicate that.
When you're looking from the bottom up you end up making different trade-offs. Because while you get nice primitives that generate very tight assembly when you need that dynamism you end up having this object model that exists in the abstract that you orchestrate and poke at but don't really see, like gobject. Ironically, HN's love-to-hate language C++ gives you both simultaneously but at the cost of a very complicated language.
