Nope. NT is designed with “not POSIX, not UNIX” ethos, and this affects the interfaces in and around the OS profoundly. You won’t be able to configure and communicate with NT kernel the way you talk with *NIX system, i.e.: with files.
You open a serial port the same way you open any file. Same call, single line.
In Windows that was 30+ lines to begin with. NT is not bad, but it’s not UNIX, and designed to be complete opposite of it. No user land can change that. Even “subsystem” functionality can’t make it replace Linux as we see today.