For example, Greg LeMond won the TdF in 1990. In 1991 he came 7th, and then never completed it again. There is some complication here because of the hunting accident he suffered in '87, but he also said "The speeds were faster and riders that I had easily outperformed were now dropping me", and the guy who won in 1991 was Indurain who was basically the first mega-doper.
Without EPO and blood doping becoming prevalent, does Greg LeMond compete for a few more years? Do other guys with similar talent who aren't willing to dope also make it to that top level. I think the answer is probably yes, and so all those guys who doped are responsible for excluding those clean athletes from the top level.