I don't do a lot of desktop apps but for simple GUI apps I've been using Python and Pywebview, with packaging left to Pyinstaller. The main reason is that I get to reuse the python/javascript/css libs that I know, and it's easily portable. I'm sure a native app uses less memory and cpu but frankly what I get with this combination is not that resource hungry. In fact, anytime something goes south it's my fault for using poor algos. Also, there are tons of great GUI libs and web components.