There are potential serious downsides if these inserted genes end up on a different chromosome than normal and become carried by gametes to offspring who may suffer from overexpression.
I presume at the point we can generate CAD like designer gene modifications, overexpression would just be another problem that can be fixed by more modification.
That was a plot device that didn't make sense to me: they could upload and download a functional copy of their brains (and also human brains), but they didn't keep a backup copy of their old DNA?
