A -2.5G event "pulls" you upward 1.5x harder than falling and you absolutely can die from falling down due to head injury - it happens all the time. In reality it doesn't pull, your inertia simply wants to keep you moving as you were so the top of the fuselage "falls" faster than gravity until it connects with your body and is able to transmit that force to counter your inertia. A better way to transmit that force is a seat belt.
This is exactly the same situation as a car hitting a wall and why you need a seat belt in that scenario too. You and the car are moving forward. The car decelerates. When it does so faster than the friction of you in the seat your inertia carries your body forward. The faster the car stops the more energy you have to impact the windshield/steering wheel/etc. The seat belt functions to transmit the force between your body and the car.