Yes, because Prohibition was such a ringing success. Just because someone says you can't do something does not prevent someone from doing that thing. If people want something badly enough, they will find a way. When that want has progressed to being a literal need from addiction, the ways found will become more and more bold/risky.
Hell, even if you added the drug that blocks the opiate receptors into the water supply like fluoride so everyone is getting dosed, addicts will just switch to bottle water. Legislation does not prevent anything. It only increases those deemed as a criminal.