Denuvo claims to have a solution to that as well, but to date it hasn't actually shown up in any games. I kind of hope at least one publisher bites just because I'm curious to find out what horrors they've cooked up to make emulation difficult.
https://irdeto.com/denuvo/nintendo-switch-emulator-protectio...
There is precedent for that kind of thing, Wii emulation matured early enough that a handful of retail games had code specifically intended to frustrate running them in Dolphin. They abused some details of the real Wiis L1/L2 cache which aren't simulated by Dolphin, and couldn't be without adding an unreasonable amount of overhead.
https://dolphin-emu.org/blog/2017/02/01/dolphin-progress-rep...