Harm mitigation isn't about sanctioning anything, it's just about recognizing that sometimes prohibition doesn't work and not making things worse in those cases.
It's about not wrecking somebody's teeth by confiscating their pacifier while they're rolling. It's about not causing overdoses by limiting access to milligram scales (because trying to use a kitchen scale to measure a dose is dangerous). It's about creating an environment where people won't lie to you if you express concern about their habits.
Most drug problems are poor dopamine hygiene or mental health issues of some other kind. Let's focus on that instead of celebrating that somebody is "off the hard stuff" while the root cause remains and wrecks their life through a video game addiction.
If you're not seeing the harms caused by overbroad vilification of drugs in general it's because the people around you who are struggling with a substance problem are hiding it from you due to your attitude about such things. And if they're hiding from you, you can't help them.