Denuvo is designed to be an extreme pain to work with in a debugger or disassembler. Every game is its own unique maze full of dead ends, fake exits, and an ever-shifting array of clever tricks to detect when the binary is being debugged or disassembled, which quietly rearrange the maze to have no solution at all.

It's extremely tedious for a human, and the pay-off is relatively low, as hinted by the parent (what recent DRMed games are even any good?). I do wonder whether anyone has tried setting a well trained AI on the problem though.