Fascism already barely works on earth, and gets out-competed. See https://tvtropes.org/pmwiki/pmwiki.php/Main/FascistButIneffi... Similarly with slavery. (See https://www.econlib.org/library/Columns/LevyPeartdismal.html to go off an slight tangent.)
In space, slavery is even less useful. That's mostly because humans are even less useful: we are already doing pretty much all of our useful space exploration with robots, and sending humans is just for bragging rights. Keeping space slaves alive costs you more than they ever could conceivably do for you.
Of course, aliens might have biologies that are much better adapted to surviving in space, maybe?
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