Sure the density isn't great as you're essentially running at 50% or raw storage but - touches wood - my home zpool has been running strong for about a decade doing the above from 6x 6tb drives (3x 6tb mirrors) to 16x 10-20tb drives (8x mirrors, differing sized drives but matched per mirror like a 10tb x2 mirror, a 16tb x2 mirror etc).
Edit: Just realised someone else as already mentioned a pool or mirrors. Consider this another +1.