A lot of I80 is really straight, same with other highways. I70 from Denver to St. Louis is incredibly boring all the way through Kansas. I90 from Wisconsin through Minnesota and South Dakota is the same. Just dead straight easy roads. Down south I10 was pretty easy too.
Just because there are a few tough stretches, that doesn't mean the auto-pilot can't drive the other thousand miles on the route, with human support where necessary.
Pick the MVP routes that are easiest. I95 is trivial from Florida, all the way up to DC. Then it remains mostly easy with some really annoying bits around DC, Philly, and NYC. I wouldn't want it trying to get through the traffic over the GW and through the Bronx, but after that it's mostly smooth all the way through Maine.