The Space Shuttle Avionics System top level documentation specifically calls out having "no Z80's, 8086s, 68000's, etc."
https://ntrs.nasa.gov/api/citations/19900015844/downloads/19...
And also, sigh, to demonstrate once again that when I worked in space it was 20 years ago, https://www.nytimes.com/2002/05/12/us/for-parts-nasa-boldly-... (https://web.archive.org/web/20230607141742/https://www.nytim...)
Knowing how 8086 timing and interrupts worked was still important for what I was doing in the early 2000s. I don't pretend to remember any of it these days.
