The most modern email client in terms of HTML/CSS support — by miles — is Apple Mail (on both macOS and iOS), which seems to support almost everything that modern Safari supports [1]. But you have to target the lowest common denominator (Outlook/Gmail), as polyfilling or progressive enhancement in emails are near impossible. GMail was once the client that revolutionized email, but then they started chasing after stuff like AMP for email and acquiring+killing other clients instead of just keeping up with standards.
Email could be such a nice technology if Google and Microsoft evolved their email clients with the same ambition as they evolved their web browsers.