Nah. Hit unsubscribe every time.
I own my own email domain, and I use a different email address per service. I have done so for 13 years.
On legitimate emails, unsubscribe works correctly almost every time.
True spam seems to originate from a handful of compromised services like LinkedIn, parkmobile, etc. I don’t hit unsubscribe on those, but I don’t see how it would make things any worse.