HR people do apply such filters, but you can usually work around it, if you're a capable individual that can actually "stack shift".

I "stack shifted" multiple times in my career, without lying about my experience. Companies look for talented software developers. Going from backend to frontend or vice versa might be harder, but otherwise the required skills pretty much universal. Having contributions on Github helps.

Of course, this is the part where I'm going to say that having a computer science and math/engineering oriented education, even if self-learned, can be valuable. People that go through their profession by just integrating off the shelf stuff will have their jobs automated.