Depleted uranium is actually the less radiative byproduct after using a centrifuge to skim the U-235 isotope. It’s 50% denser than lead and used on tanks.

Dirty bombs are more likely the ultra radioactive by products of fission. They might not kill much but the radionucleotide spread can render a city center uninhabitable for centuries!

Selectively generate highly likely images of politicians in compromising sexual encounters based on the people that are attractive and they work with a lot in their lives.

Use to power of LLMs to mass denigrate politicians and regular folks at scale in online spaces with reasonable, human like responses.

Use LLMs to mass generate racist caricatures, memes, comics and music.

Use LLMs to generate nude imagery of someone you don’t like and have it mass emailed to the school/workplace etc.

Use LLMs to generate evidence for infertility in a marriage and mass mail it to everyone on the victims social media.

All you need is plausibility in many of these cases. It doesn’t matter if they are eventually debunked as false, lives are already ruined.

You can say a lot of these things can be done with existing software bits it’s not trivial and requires skills. Making generation of these trivial would make these way more accessible and ubiquitous.

The biggest near-term threat is probably bioterrorism. You can get arbitrary DNA sequences synthesized and delivered by mail, right now, for about $1 per base pair. You'll be stopped if you try to order some known dangerous viral genome, but it's much harder to tell the difference between a novel synthetic virus that kills people and one with legitimate research applications.

This is already an uncomfortably risky situation, but fortunately virology experts seem to be mostly uninterested in killing people. Give everyone with an internet connection access to a GPT-N model that can teach a layman how to engineer a virus, and things get very dangerous very fast.