I first just went through it front to back, having a go at some of the simpler ones as I went. Since then, I've mostly just picked ones that felt interesting to learn. I've been a bit partial to more decorative stuff lately: a few of the sinnets, Full Matthew Walker, Turks-Heads, that sort of thing.

I'd say my favourite one is one I come up with based on a Sheepshank, but (to the surprise of no one) was in the book as #1148 (Bell Ringer with two hitches). My use case, however, is as a double-noose to carry bags. Once tied, you can tighten one loop by loosening the second, then tighten the second by pulling the standing part. I tighten these around the neck of the two bags beneath the knots, then use a Marlingspike Hitch in the standard part with a piece of wood as a handle.