From where I stand I can’t see anyone giving a clear explanation of anything our brain does or does not do in a disease. The only novel treatment that has come out seems to have been stick a rod into the brain and zap it and it just magically cures a lot of diseases we still don’t understand even a bit.

This is not even starting to discuss what little we have learned about how brains algorithms work. I’m still waiting to understand why pyramidal neurons were somehow groundbreaking. We found some neuron that fires when you walk to a place, why wouldn’t we find one?

And what are you saying about the fly connectome again? Do we have exact names for every neuron in the fly brain and its verified connectome for every neuron?

Last I checked the worm connectome has been available in intricate detail for decades and the scientists still haven’t had any proper decoding of the algorithms in that system. In fact I know every lab trying to figure that out now, I wrote proposals in the topic myself. Everyone else has apparently decided it’s not sexy enough to work with worms so they have just leaped to more complex systems with no basic understanding. I’m not the only one saying this. Sydney Brenner said as much in an editorial. But the field was too busy doing I don’t know what to listen.

Sydney, B. & Sejnowski, T. J. Understanding the human brain. Science 334, 567 (2011).

I remember sauntering to the occasional neuroscience talk during my ut southwestern PhD and occasionally hearing some professor brag about how the majority of one of their PhD’s jobs was to segmenting a single neuron in the thousand EM images or something. Surely that’s a sign this field needs revision?

A surface review of neuroplasticity literature alone should free anyone of the illusion that “neural networks” have even a passing resemblance to biological neurons, something covered in neuroscience 101 and is widely internalized by its practitioners. The BS grant writing and PR scientists have to participate in is hardly reflect of state of the art science itself.

The irony is that machine learning methods are a perfect fit for neuroscience and biology in general which generates reams of data that is largely so multidimensional that manual analysis is intractable. What we’re seeing now is the crest of the academic hype cycle which - if the history of bioinformatics is anything to go by - means that ML will take years if not decades for the field to understand and filly utilize.