1. https://braininitiative.nih.gov/sites/default/files/document...
I certainly have many critiques of methods used in neuroscience rn (as a working neuroscientist) but to reduce those to the conclusion that the entire project of neuroscience is hopeless is absurd. We understand certain things quite well actually, and it's not at all obvious what "understanding" at a larger scale would look like. It is very possible that the brain is irreducibly complex, and that the model you would need to construct to describe it would itself be so complex as to be useless in providing insight. Considering that the brain is by far the most complex object in the universe I think we're doing pretty well.
Furthermore, there are quite a lot of disagreements about the utility of connectomics. Outside of the extremists (Sebastian Seung and his ilk) no one thinks that connectomics is going to be the key that brings earth shattering insight. It's just another tool. There is a complete connectome for part of the drosophila brain already (privately funded btw), which is in daily use in many fly labs. It tells you what other neurons are connected to. Incredibly useful. Not earth shattering.
also you might want to measure the neuroscience funding you deem wasteful up against the tens of billions NASA is spending to send humans (and not robots) back to the moon for "the spirit of adventure". cold war's over. robots will do just fine for the moon.
From where I stand I can’t see anyone giving a clear explanation of anything our brain does or does not do in a disease. The only novel treatment that has come out seems to have been stick a rod into the brain and zap it and it just magically cures a lot of diseases we still don’t understand even a bit.
This is not even starting to discuss what little we have learned about how brains algorithms work. I’m still waiting to understand why pyramidal neurons were somehow groundbreaking. We found some neuron that fires when you walk to a place, why wouldn’t we find one?
And what are you saying about the fly connectome again? Do we have exact names for every neuron in the fly brain and its verified connectome for every neuron?
Last I checked the worm connectome has been available in intricate detail for decades and the scientists still haven’t had any proper decoding of the algorithms in that system. In fact I know every lab trying to figure that out now, I wrote proposals in the topic myself. Everyone else has apparently decided it’s not sexy enough to work with worms so they have just leaped to more complex systems with no basic understanding. I’m not the only one saying this. Sydney Brenner said as much in an editorial. But the field was too busy doing I don’t know what to listen.
Sydney, B. & Sejnowski, T. J. Understanding the human brain. Science 334, 567 (2011).
I remember sauntering to the occasional neuroscience talk during my ut southwestern PhD and occasionally hearing some professor brag about how the majority of one of their PhD’s jobs was to segmenting a single neuron in the thousand EM images or something. Surely that’s a sign this field needs revision?
onus isn't on me to justify the existence of an entire field to you. the claim that neuroscience has not made great strides in the last 30 years is an extraordinary one, and that's all on you. but it especially doesn't help your case that if you had googled "fly connectome " you would have seen that the first result is a complete connectome of a larvae and the third result is the tour de force from Janelia that produced an adult connectome. With names and verified connections. there is even a wikipedia article for the drosophila connectome!
> I remember sauntering to the occasional neuroscience talk during my ut southwestern PhD and occasionally hearing some professor brag about how the majority of one of their PhD’s jobs was to segmenting a single neuron in the thousand EM images or something. Surely that’s a sign this field needs revision?
and if you had gone on to actually read the hemibrain connectome paper you would have gained some appreciation for the gargantuan achievement that it was. it took hundreds of person years to generate ground truth segmenting neurons by hand, to develop the ML techniques required to automatically segment the rest (extremely difficult problem) and to then validate the automatic segmentations. not to mention the insane effort it was to acquire a half petabyte EM image of a single fly at sub-synaptic resolution in the first place.
I gotta hand it to you though, the position of naivety you've delivered your middlebrow dismissal from is truly impressive in magnitude.
A surface review of neuroplasticity literature alone should free anyone of the illusion that “neural networks” have even a passing resemblance to biological neurons, something covered in neuroscience 101 and is widely internalized by its practitioners. The BS grant writing and PR scientists have to participate in is hardly reflect of state of the art science itself.
The irony is that machine learning methods are a perfect fit for neuroscience and biology in general which generates reams of data that is largely so multidimensional that manual analysis is intractable. What we’re seeing now is the crest of the academic hype cycle which - if the history of bioinformatics is anything to go by - means that ML will take years if not decades for the field to understand and filly utilize.
